Correlation Between Cytokinetically Resting Lymphocytes and Bone Marrow Restoration: Experiments Using a Discontinuous Albumin Gradient

Correlation between cytokinetically resting lymphocytes and bone marrow restoration: experiments using a discontinuous albumin gradient.

The Role of Bone Marrow Aspiration and Bone Marrow Biopsy in Diagnosis of Bone Marrow Metastases

Background: Bone marrow is the site of many malignant disorders and it is one of the common places for solid tumors to metastasize. Examination of the bone marrow aspirate and biopsy is a routine procedure performed for assessment of various conditions such as cytopenias, hematologic neoplasms, nonmalignant disorders and metastatic neoplasms. Methods: The patients were referred to the Hema...

Detection of small cell lung cancer bone marrow involvement by discontinuous gradient sedimentation.

Marrow involvement by small cell lung cancer (SCLC) is detected in 10-23% of patients at initial diagnosis by marrow aspirate and biopsy techniques. To improve the detection and potentially monitor marrow involvement by SCLC we have attempted to concentrate malignant cells with clonogenic potential on a discontinuous density gradient (DDG). The bone marrow from 43 patients with SCLC (36 with hi...

Immunological Tolerance in Bone Marrow-derived Lymphocytes

The studies presented here have focused on the important question of reversibility of inactivation of DNP-specific B lymphocytes induced by the DNP derivative of the copolymer of D-glutamic acid and D-lysine (D-GL). In so doing, we have analyzed the capacity of a strong T-cell stimulus, such as that provided by the allogeneic effect, and of gentle enzymatic treatment with trypsin to alter, prev...

Thymus-dependent lymphocytes in human bone marrow.

Human bone marrow is known to contain significant numbers of bursa-dependent lymphocytes. The presence of thymus-dependent (T) cells is controversial. Bone marrow cells obtained from healthy volunteers was fractionated by density centrifugation. A lymphocte-enriched subpopulation was shown to be reactive to alloantigens in mixed lymphocyte culture and to contain substantial numbers of T lymphoc...